Extracellular Vesicles and Their Role in Immunomodulation and Cancer
Extracellular vesicles (EVs) including exosomes, microvesicles, and apoptotic bodies are membrane-bound vesicles which are secreted by almost all cell types to the cellular microenvironments and circulation. EVs contain bioactive cargoes such as antigens, cytokines, chemokines, membrane proteins, lipids, microRNAs, and long non-coding RNAs that have the ability to elicit cellular responses. EVs can be released by and also be targeted toward immune cells and act as key mediators of cellular communications. EVs carry specific molecular signatures reflecting the status of parental cells at the time of release. EVs can modulate a variety of immune responses including antigen presentation, immune activation and suppression, immune cell polarization, immune cell migration. EVs can also act as regulator of tumor microenvironments and bone marrow premetastatic and metastatic niche formation in cancer and are emerging as one of the main players of immuno-oncology. The field of EVs is a very active and expanding growing area of research in recent years.
The aim of this Research Topic is to provide a comprehensive overview of the novel discovery in the emerging field of EVs in immunity. We seek submission of Original Research articles, Reviews, Mini-Reviews, Methods, Protocols, Perspective, and Technology Report that address, but not limited to, the following topics:
1. Role of EVs cross-talk of immune and non-immune cells.
2. Role of EVs in signaling events in immune cells.
3. Immunoregulatory effect of tumor-derived EVs.
4. Role of EVs in cancer immunotherapy.
5. Role of EVs in inflammation and autoimmune related conditions/diseases.
6. Novel methods and concepts for studying EVs in immune regulation.
Journal of Cancer Research and Immuno-Oncology
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